Publikationen der AG Zellkulturtechnik seit 2005

Peer reviewed Journals

2016

Wippermann A, Rupp O, Brinkrolf K, HOffrogge R, Noll T (2016), Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells, J Biotechnol, htto://dx.doi.org/10.1016/j.jbiotec.2016.11.020


Beatson R, Tajadura-Ortega V, Achkova D, Picco G, Tsourouktsoglou TD, Klausing S, Hillier M, Maher J, Noll T, Crocker PR, Taylor-Papadimitriou J, Burchell JM (2016), MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9, Nature Immunology, 17(11): 1273-81 

 

Coronel J, Klausing S, Heinrich C, Noll T, Figueredo-Cardero A, Castilho LR (2016), Valeric acid supplementation combined to mild hypothermia increases productivity in CHO cell cultivations, Biochemical Engineering Journal, 114:101-109

 

2015

Brandenbusch C, Glonke S, Collins J, Hoffrogge R, Grunwald K, Bühler B, Schmid A, Sadowski G (2015), Process Boundaries of Irreversible scCO2-assisted Phase Separation in Bi-Phasic Whole Cell Biocatalysis, Biotechnol Bioeng, doi: 10.1002/bit.25655

 

Wippermann A, Brinkrolf K, Rupp O, Hoffrogge R, Noll T (2015), The DNA methylation landscape of Chinese Hamster Ovary (CHO) DP-12 cells, J Biotechnol, 199:38-46

 

Wingens M, Gaetgens J, Schmidt A, Albaum SP, Buentemeyer H, Noll T, Hoffrogge R (2015), 2D-DIGE screening of high-productive CHO cells under glucose limitation - Basic changes in the proteome equipment and hints for epigenetic effects, J Biotechnol, 201:86-97

 

2014

 

Jakobi T, Brinkrolf K, Tauch A, Noll T, Stoye J, Puehler A, Goesmann A (2014), Discovery of transcription start sites in the Chinese hamster genome by next-generation RNA sequencing, J Biotechnol 190:64-75

 

Lohr V, Hädicke O, Genzel Y, Jordan I, Büntemeyer H, Klamt S, Reichl U (2014), The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis, BMC Biotechnology 2014, 14:72

 

Noll T, Puehler A, Weisshaar B, Wendisch VF (2014), The genomics revolution and its impact on future biotechnology, J Biotechnol 190:1

 

Wippermann A, Klausing S, Rupp O, Albaum SP, Buentemeyer H, Noll T, Hoffrogge R (2014), Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells, Appl Microbiol Biotechnol 98(2): 579-89

 

Rath AG, Rehberg M, Janke R, Genzel Y, Scholz S, Noll T, Rose T, Sandig V, Reichl U (2014), The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells, J Biotechnol 178: 43-53

 

Becker J, Timmermann C, Klausing S, Rupp O, Brinkrolf K, Goesmann A, Tauch A, Noll T (2014),Transcriptome analyses of CHO cells with the next-generation microarray CHO41K:development and validation by analysing the influence of the growth stimulating substance IGF-1 substitute LongR3, J Biotechnol 178:23-31

 

Rupp O, Becker J, Brinkolf K, Timmermann C, Borth N, Pühler A, Noll T, Goesmann A (2014), Construction of a public CHO celline transcipt database using versatile bioinformatics analysis pipelines, PLOS ONE, 9(1): e85568. doi:10.1371/journal.pone.0085568

 

2013

Klenke C, Widera D, Engelen T, Müller J, Noll T, Niehaus K, Schmitz ML, Kaltschmidt B, Kaltschmidt C (2013) Hsc70 Is a Novel Interactor of NF-kappaB p65 in Living Hippocampal Neurons, PLOS ONE 8(6): e65280

 

Brinkrolf K, Rupp O, Laux H, Kollin F, Ernst W, Linke B, Kofler R, Romand S, Hesse F, Budach WE, Galosy S, Müller D, Noll T, Wienberg J, Jostock T, Leonard M, Grillari J, Tauch A, Goesmann A, Helk B, Mott JE, Pühler A and Borth N (2013), Chinese hamster genome sequenced from sorted chromosomes, Nature Biotechnology, 31(8): 694-5

 

Wippermann A, Klausing S, Rupp O, Albaum SP, Büntemeyer H, Noll T, Hoffrogge R (2013), Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells, Appl Microbiol Biotechnol, DOI 10.1007/s00253-013-5282-2    [download]

 

Freund S, Rath A, Platas Barradas O, Skerhutt E, Scholz S, Niklas J, SandigV, Rose T, Heinzle E, Noll T, Pörtner R, Zeng AP, Reichl R (2013), Batch-to-batch variability of two human designer cell lines AGE1.HN and AGE1.HN.AAT carried out by different laboratories under defined culture conditions using a mathematical model, Engineering in Life Sciences 03/2013; DOI:10.1002/elsc.201200111

 

2012

Platas Barradas O, Jandt U, Da Minh Phan L, Villanueva ME, Schaletzky M, Rath A, Freund S, Reichl U, Skerhutt E, Scholz S, Noll T, Sandig V, Pörtner R, Zeng AP (2012), Evaluation of criteria for bioreactor comparison and operation  standardization for mammalian cell culture, Eng. Life Sci. 12(5): 1–11

 

Carrondo M, Alves P, Carinhas N, Glassey J, Hesse F, Merten OW, Micheletti M, Noll T, Freitas Oliveira RM, Reichl U, Staby A, Teixeira A, Weichert H, Mandenius CF (2012), How can measurement, monitoring, modelling and control advance cell culture in industrial biotechnology?, Biotechnol J, accepted

 

Hackl M, Jadhav V, Jakobi T, Rupp O, Brinkrolf K, Goesmann A, Pühler A, Noll T, Borth N, Grillari J (2012) Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines, J Biotechnol, 158(3): 151-5

 

Meleady P, Hoffrogge R, Henry M, Rupp O, Bort JH, Clarke C, Brinkrolf K, Kelly S, Müller B, Doolan P, Hackl M, Beckmann T, Noll T, Grillari J, Barron N, Pühler A, Clynes M, Borth N (2012), Utilisation and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics, Biotechnol Bioeng, 109(6): 1386-94

 

Beckmann TF, Krämer O, Klausing S, Heinrich C, Thüte T, Büntemeyer H, Hoffrogge R, Noll T (2012), Effects of high passage cultivation on CHO cells: a global analysis, Appl. Microbiol Biotechnol, 94:659-71

 

2011

 Becker J., Hackl M, Jakobi T, Rupp O, Schneider J, Szczepanowski R, Bekel T, Borth N, Goesmann A, Grillari J, Kaltschmidt C, Noll T, Pühler A, Tauch A, Brinkrolf K (2011), Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing, J Biotechnology, 156(3): 227-35

 

Volmer M, Northoff S, Scholz S, Thüte T, Büntemeyer H, Noll T (2011) Fast Filtration for Metabolome Sampling of Suspended Animal Cells, Biotechnology Letters, 33(3):495-502

 

Niklas J, Schräder E, Sandig V, Noll T, Heinzle E (2011) Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis, Bioprocess Biosystems Engineering, 34(5):533-45

 

Lenger J, Schröder M, Ennemann E, Müller B, Wong CH, Noll T, Dierks T, Hanson SR and Sewald N, (2011), Evaluation of Sulfatase-Directed Quinone Methide Traps for Proteomics, Bioorg Med Chem, 20:622-27

 

2010

Krämer O, Klausing S, Noll T (2010) Methods in mammalian cell line engineering: from random mutagenesis to sequence-specific approaches, Applied Microbiology and Biotechnology, 88(2):425-436

 

Burgemeister S, Nattkemper T, Noll T, Hoffrogge R, Flaschel E (2010) CellViCAM - Cell Viability Classification for Animal Cell Cultures using Dark Field Micrographs, Journal of Biotechnology, 149(4):310-316

 

2009

Kubitzki T, Minör D, Mackfeld U, Noll T, Oldiges M, Lütz S (2009) Application of immobilized bovine enterokinase in repetitive fusion protein cleavage for the production of MUC1, Biotechnology Journal, 4(11):1610-8

 

Batista FRX, Ângela M. Moraes AM, Büntemeyer H, Noll T (2009) Influence of Culture Conditions on Recombinant Drosophila melanogaster S2 Cells Producing the G Glycoprotein from the Surface of Rabies Virus Cultivated in Serum-Free Medium, Biologics, 2009, 37:108

 

Widera D, Zander C, Heidbreder M, Kasperek Y,  Noll T, Seitz O, Saldamli B, Sudhoff H, Sader H, Kaltschmidt C and Kaltschmidt B (2009) Adult palatum as a novel source of neural-crest related stem cells, Stem Cells, Stem Cells 27(8):1899-910

 

Sihlbom C, van Dijk Härd I, Lidell ME, Noll T, Hansson GC, Bäckström M (2009) Localisation of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometry, Glycobiology, 19(4):375-81

 

Magin AS, Körfer N, Partenheimer H, Lange C, Zander A, Noll T (2009) Primary cells as feeder cells for clinical co-culture expansion of human hematopoietic stem cells from umbilical cord blood – a comparative study, Stem Cell and Development 8(1):173-86

 

2008

Kubitzki T, Noll T, Lütz S (2008) Immobilisation of bovine enterokinase and application of the immobilised enzyme in fusion protein cleavage, Bioprocess Biosyst Eng. 2008, 3:173-82

 

Grimshaw MJ, Papazisis K, Picco G, Bohnenkamp HR, Noll T, Taylor-Papadimitriou J, Burchell J (2008) Immunisation with ‘naïve’ syngeneic dendritic cells protects mice from tumour challenge, Br J Cancer. 98(4):784-91

 

Schweppe CH, Bielaszewska M, Pohlentz G, Friedrich AW, Büntemeyer H, Schmidt MA, Kim KS, Peter-Katalinic J, Karch H, Müthing J (2008) Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with different Shiga toxin 1 cytotoxicity, Glycoconj J,  25:291-304

 

Niebruegge S, Nehring A, Bär H, Schroeder M, Zweigerdt R, Lehmann J (2008), Cardiomyocyte production in mass suspension culture: embryonic stem cells as a source for great amounts of functional cardiomyocytes, Tissue Eng Part A, 14(10):1591-601

 

2007

Wiendahl C, Brandner J, Küppers C, Luo B, Schygulla U, Noll T, Oldiges M (2007), A microstructure heat exchanger for quenching the metabolism of mammalian cells, Chem Eng Technol, 30(3): 322-28

 

Hoffrogge R., Beyer S., Hubner R., Mikkat S., Mix E., Scharf C., Schmitz U., Pauleweit S., Berth M., Zubrzycki I.Z., Christoph H., Pahnke J., Wolkenhauer O., Uhrmacher A., Volker U., Rolfs A. (2007), 2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells. Proteomics: 7(1): 33-46

 

Beyer S, Mix E, Hoffrogge R, Lünser K, Völker U, Rolfs A (2007), Neuroproteomics in stem cell differentiation. Clinical Proteomics 1 (11): 1513 - 1523

 

2006

Hoffrogge R., Mikkat S., Scharf C., Christoph H., Beyer S., Pahnke J., Mix E., Berth M., Uhrmacher A., Zubrycki I., Miljan E., Völker U., Rolfs A. (2006), 2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM). Proteomics: 6(6): 1833-47

 

Hoffrogge R., Beyer S., Völker U., Uhrmacher A., Rolfs A. (2006), 2-DE proteomic profiling of neuronal stem cells. Neurodegenerative Dis 3: 112-121

 

Mix E., Ibrahim S.M., Pahnke J., Glass A., Mazon-Pelaez I., Lemcke S., Koczan D., Gimsa U., Bansemer S., Scheel T., Karopka T., Bottcher T., Muller J., Dazert E., Antipova V., Hoffrogge R., Wree A., Zschiesche M., Strauss U., Kundt G., Warzok R., Gierl L., Rolfs A. (2006), 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE. J Autoimmun. 27(4):251-65

 

Guthke R, zeilinger K, Sickinger S, Schmidt-Heck W, Büntemeyer H, Iding K, Lehmann J, Pfaff M, Pless G, Gerlach JC (2006), Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors, Bioprocess Biosys Eng, 28: 331-340

 

Sewell R, Dalziel M, Backstrom M, Hansson G, Noll T, Clausen H, Burchell J, Taylor-Papadimitriou J (2006) Human ST6GalNAcI is responsible for the expression of the sialyl-Tn O-glycan in breast cancers, J Biol Chem, 281:3586-94

 

2005 

Bohnenkamp HR, Burchell J, Taylor-Papadimitriou J, Noll T (2005) Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cells, Journal of Immunol Methods, 294(1-2):67-80.

 

Rughetti A, Pellicciotta I, Biffoni M, Bäckström M, Link T, Noll T, Hansson GC, Clausen H, Burchell JM, Taylor-Papadimitriou J, Nuti M (2005) Recombinant   tumor associated   MUC1  impairs differentiation  and function of Dendritic Cells, Journal of Immunology, 174(12):7764-72    

 

Markotic A, Culic VC, Kurir TT, Meisen I, Büntemeyer HBoraska V, Zemunik T, Petri N, Mesaric M, Peter-Katalinic J, müthing J (2005), Oxygenation alters ganglioside expression in rat liver following partial hepatectomy, Biochem Biophys Res Commun, 330: 131-141

 

Schroeder M, Niebruegge S, Werner A, Willbold E, Burg M, Ruediger M, Field LJ, Lehmann J, Zweigerdt R (2005), Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control, Biotechnol Bioeng, 92(7):920-33

 

Proceedings

2013

Wippermann A, Klausing S, Rupp O, Noll T, Hoffrogge R (2013), First CpG island micrarray for genome-wide analyses o DNA methylation i chinese hamster ovary cells: new insights into the epigenetic answer to butyrate treatment, BMC Proceedings 2013, 7(Suppl 6):O5

 

Gettmann J, Timermann C, Becker J, Thüte T, Rupp O, Büntemeyer H, Lohmeier A, Scholz S, Goesmann A (2013) Multidimension cultivation analysis by standard and omics methods for optimization of therapeutics production, BMC Proceedings 2013, 7(Suppl 6):P5

 

Lohmeier A, Northoff S, Munro T, Noll T (2013) Effects of perfusion processes under limiting conditions on different Chinese Hamster Ovary cells, BMC Proceedings 2013, 7(Suppl 6):P64

 

Klausing S, Krämer O, Noll T (2013) Enhancing cell growth and antibody production in CHO cells by siRNA knockdown of novel target genes, BMC Proceedings 2013, 7(Suppl 6):P92

 

Aretz J, Thüte T, Scholz S, Kersting K, Noll T, Büntemeyer H (2013) Understanding cell behavior in cultivation processes - A metabolic approach, BMC Proceedings 2013, 7(Suppl 6):P90

 

2011

Skerhutt EM, Scholz S, Sandig V, Hoffrogge R, Noll T (2011) Analysis of the mitochondrial subproteome of the human cell line AGE1.HN–a contribution to a systems biology approach. BMC Proceedings, 5 (8)


Skerhutt EM, Scholz S, Niklas J, Rath A, Platas Barradas O, Jandt U, Sandig V, Rose T, Pörtner R, Reichl U, Zeng A-P, Heinzle E, Noll T (2011) Characterisation of cultivation of the human cell line AGE1.HN.AAT. BMC Proceedings, 5 (8)


Scholz S, Miriam L, Alexander R, Schräder EM, Thomas R, Büntemeyer H, Thomas S, Udo R, Noll T (2011) Characterization of the human AGE1.HN cell line: a systems biology approach. BMC Proceedings, 5 (8)

 

Platas Baradas O, Jandt U, Da Minh Phan L, Villanueva M, Rath A , Reichl U, Schräder EM, Scholz S, Noll T, Sandig V, Pörtner R, Zeng AP (2011) Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture. BMC Proceedings, 5 (8)


Klausing S, Krämer O, Noll T (2011) Bioreactor cultivation of DP-12 cells under sodium butyrate treatment–comparative transcriptome analysis with CHO cDNA microarrays. BMC Proceedings, 5 (8)


Volmer M, Gettmann J, Scholz S, Büntemeyer H, Noll T (2011) A method for metabolomic sampling of suspended animal cells using fast filtration. BMC Proceedings, 5 (8)

 

Beckmann T, Thüte T, Heinrich C, Büntemeyer H, Noll T (2011) Proteomic and metabolomic characterization of DP-12 cell lines with different high passage histories. BMC Proceedings, 5 (8)


Heinrich C, Timo W, Christina K, Northoff S, Noll T (2011) Growth characterization of CHO DP-12 cell lines with different high passage histories. BMC Proceedings, 5 (8)


Becker J, Timmermann C, Jakobi T, Rupp O, Szczepanowski R, Hackl M, Goesmann A, Tauch A, Borth N, Grillari J, Pühler A, Noll T, Brinkrolf K (2011) Next-generation sequencing of the CHO cell transcriptome. BMC Proceedings, 5 (8)

 

2010

Nottorf T, Büntemeyer H, Siwiora-Brenke S, Lütkemeyer D, Loa A, Noll T, Lehmann J (2010), An integrated production process for human growth hormone, Noll (ed.), ‘Cells & Culture’, Springer, 205-8

 

Wingens M, Gätgens J, Hoffrogge R, Noll T (2010), Proteomic characterization of a glucose-limited CHO perfusion process-analysis of metabolic changes and increase in productivity, Noll (ed.), ‘Cells & Culture’, Springer, 265-70

 

Bäckström M, Karlsson H, Gätgens J, Noll T, Hansson GC (2010), O-glycans on recombinant MUC1 produced in CHO K1 cells becomes less sialylated with increased productivity as determined by LC ESI MS, Noll (ed.), ‘Cells & Culture’, Springer, 285-8

 

Wiendahl C, Brandner JJ, Klein B, Küppers C, Luo B, Ritchie S, Mazurek S, Scheefers H, Noll T, Schygulla U, Oldiges M (2010), Metabolome analysis in mammalian cells: Development and application of a sampling technique, Noll (ed.), Cells & Culture, Springer, 413-20

 

Northoff S, Sandig V, Zietze S, Büntemeyer H, Noll T (2010), Characterization of the novel human AGE1hn cell line for production of recombinant proteins, Noll (ed.), ‘Cells & Culture’, Springer, 693-8

 

2007

Nottorf T, Hoera W, Büntemeyer H, Siwiora-Brenke S, Loa A, Lehmann J (2007), Production of human growth hormone in a mammalian cell high density perfusion process, Smith (ed) ‘Cell Technology for Cell Products’, Springer, Dordrecht, 789-793

 

Schaper J, Bohnenkamp HR, Noll T (2007), New electrofusion devices for the improved generation of dendritic cell-tumour cell hybrids, Smith (ed) ‘Cell Technology for Cell Products’, Springer, 207-216

 

Lamlé J, Büntemeyer H, Reinel A, Menne T, van den Bos C, Lehmann J (2005), Propagation of USSC for theraoeutic approaches, Smith (ed) ‘Cell Technology for Cell Products’, Springer, 325-329

 

Bauwens A, Büntemeyer H, Terstegge S, Nottorf T, Brüstle O, Lehmann J (2007), Bioreactor based production of functional conditioned medium for the propagation of undifferentiated human embryonic stem cells, Smith (ed) ‘Cell Technology for Cell Products’, Springer, 331-334

 

Jockwer A, Klinger C, Gätgens J, Eisenkrätzer D, Noll T (2007), Towards pCO2-optimized fermentations – reliable sampling, pCO2 control & cellular metabolism, Smith (ed) ‘Cell Technology for Cell Products’, Springer, 509-518

 

Schomberg M, Hakemeyer C, Buentemeyer H, Stiens L, Lehmann J (2007), Growth promoting effect of a hydrolysate primatone on hybridoma cells (2007), Smith (ed) `Cell Technology for Cell Products´, Springer, 141 - 146

 

Niebruegge S, Ebelt H, Jungblut M, Baer H, Schroeder M, Zweigerdt R, Braun T, Lehmann J, (2007), `Generation of Cardiomyocytes derived from mouse ESC in a Scale-up System, Smith (ed) `Cell Technology for Cell Products´, Springer, 191 – 195

 

Nottorf T, Hoera W, Buentemeyer, Siwiora-Brenke S, Loa A, Lehmann J, (2007), Production of human growth hormone in a mammalian cell high density perfusion process, `Cell Technology for Cell Products´, Springer, 789 – 793

 

2005 

Link T, Essers R, Zörner K, de Graaf A, Bäckström M, Hansson G, Noll T (2005) Development of metabolically optimized fermentation process based on glucose-limited CHO perfusion culture, Godia (ed.) ‘Animal Cell Technology meets Genomics’, Kluwer Academic Publishers, Dordrecht, 423-30  

 

Fischbach, Noll T (2005) Membrane-separated cocultivation of cord blood hematopoietic stem cells with stromal cell lines, Godia (ed.) ‘Animal Cell Technology meets Genomics’, Kluwer Academic Publishers, 269-71

 

Bohnenkamp HR, Noll T (2005) Process development for standardized generation of monocyte-derived dendritic cells: Applicability in breast cancer immunotherapy, Godia (ed.) ‘Animal Cell Technology meets Genomics’, Kluwer Academic Publishers, 221-27

 

Schomberg M, Hakemeyer C, Büntemeyer C, Stiens L, Lehmann J (2005), Growth promoting effect of a hydrophilic fraction of the protein hydrophilic fraction of the protein hydrolysate Primatone on hybridoma cells, Smith (ed) ‘Cell Technology for Cell Products’, Springer, Dordrecht, 141-146

 

Iding K, Buentemeyer H, Lehmann, J (2005), Non-freezing preservation and subsequent recovery of hepatocytes uner pO2 – and pH-controlled conditions for continuous suppy of cells for bioartificial liver support, Gòdia, Fussenegger (eds) `Animal Cell Technology meets Genomics´, Springer, 167 – 170

 

Schroeder M, Niebruegge S, Werner A, Zweigerdt R, Burg M, Lehmann J, (2005), Optimizing the production of cardiomycytes from mouse embryonic stem cells in a 2L stirred tank reactor,Gòdia, Fussenegger (eds) `Animal Cell Technology meets Genomics´, Springer, 285 – 288