Publications since 2002



Peer reviewed Journals



Niklas J, Schräder E, Sandig V, Noll T, Heinzle E (2009) Time resolved 13C-metabolic flux analysis characterizes growth phases of the new human cell line


Herbold, R; Carl, W; Canzoneri, M; Arnold, M; Noll, T (2009) Development and characterisation of a small-scaled, stirred cultivation system with oxygen and pH control


Kremling A, Vellejo-Perez S, Gerlach JC, Büntemeyer H, Zeilinger K (2009) A stoichiometric model describes flux distributions in primary human liver cells cultured in perfused 3D multcompartment bioreactors



Kubitzki T, Minör D, Mackfeld U, Noll T, Oldiges M, Lütz S (2009) Application of immobilized bovine enterokinase in repetitive fusion protein cleavage for the production of MUC1, Biotechnology Journal, accepted


Batista FRX, Ângela M. Moraes AM, Büntemeyer H, Noll T (2009) Influence of Culture Conditions on Recombinant Drosophila melanogaster S2 Cells Producing the G Glycoprotein from the Surface of Rabies Virus Cultivated in Serum-Free Medium, Biologics, 2009, 37:108


Widera D, Zander C, Heidbreder M, Kasperek Y,  Noll T, Seitz O, Saldamli B, Sudhoff H, Sader H, Kaltschmidt C and Kaltschmidt B (2009) Adult palatum as a novel source of neural-crest related stem cells, Stem Cells. in press



Sihlbom C, van Dijk Härd I, Lidell ME, Noll T, Hansson GC, Bäckström M (2008) Localisation of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometry, 2008 Dec 18. [Epub ahead of print]


Magin AS, Körfer N, Partenheimer H, Lange C, Zander A, Noll T (2008) Primary cells as feeder cells for clinical co-culture expansion of human hematopoietic stem cells from umbilical cord blood – a comparative study, Stem Cell and Development, 2008 May 9. [Epub ahead of print]


Kubitzki T, Noll T, Lütz S (2008) Immobilisation of bovine enterokinase and application of the immobilised enzyme in fusion protein cleavage, Bioprocess Biosyst Eng. 2008, 3:173-82


Grimshaw MJ, Papazisis K, Picco G, Bohnenkamp HR, Noll T, Taylor-Papadimitriou J, Burchell J (2008) Immunisation with ‘naïve’ syngeneic dendritic cells protects mice from tumour challenge, Br J Cancer. 98(4):784-91


Schweppe CH, Bielaszewska M, Pohlentz G, Friedrich AW, Büntemeyer H, Schmidt MA, Kim KS, Peter-Katalinic J, Karch H, Müthing J (2008) Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with different Shiga toxin 1 cytotoxicity, Glycoconj J,  25:291-304


Niebruegge S, Nehring A, Bär H, Schroeder M, Zweigerdt R, Lehmann J (2008), Cardiomyocyte production in mass suspension culture: embryonic stem cells as a source for great amounts of functional cardiomyocytes, Tissue Eng Part A, 14(10):1591-601



Wiendahl C, Brandner J, Küppers C, Luo B, Schygulla U, Noll T, Oldiges M (2007), A microstructure heat exchanger for quenching the metabolism of mammalian cells, Chem Eng Technol, 30(3): 322-28


Hoffrogge R., Beyer S., Hubner R., Mikkat S., Mix E., Scharf C., Schmitz U., Pauleweit S., Berth M., Zubrzycki I.Z., Christoph H., Pahnke J., Wolkenhauer O., Uhrmacher A., Volker U., Rolfs A. (2007), 2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells. Proteomics: 7(1): 33-46


Beyer S, Mix E, Hoffrogge R, Lünser K, Völker U, Rolfs A (2007), Neuroproteomics in stem cell differentiation. Clinical Proteomics 1 (11): 1513 - 1523



Hoffrogge R., Mikkat S., Scharf C., Christoph H., Beyer S., Pahnke J., Mix E., Berth M., Uhrmacher A., Zubrycki I., Miljan E., Völker U., Rolfs A. (2006), 2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM). Proteomics: 6(6): 1833-47


Hoffrogge R., Beyer S., Völker U., Uhrmacher A., Rolfs A. (2006), 2-DE proteomic profiling of neuronal stem cells. Neurodegenerative Dis 3: 112-121


Mix E., Ibrahim S.M., Pahnke J., Glass A., Mazon-Pelaez I., Lemcke S., Koczan D., Gimsa U., Bansemer S., Scheel T., Karopka T., Bottcher T., Muller J., Dazert E., Antipova V., Hoffrogge R., Wree A., Zschiesche M., Strauss U., Kundt G., Warzok R., Gierl L., Rolfs A. (2006), 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE. J Autoimmun. 27(4):251-65


Guthke R, zeilinger K, Sickinger S, Schmidt-Heck W, Büntemeyer H, Iding K, Lehmann J, Pfaff M, Pless G, Gerlach JC (2006), Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors, Bioprocess Biosys Eng, 28: 331-340


Sewell R, Dalziel M, Backstrom M, Hansson G, Noll T, Clausen H, Burchell J, Taylor-Papadimitriou J (2006) Human ST6GalNAcI is responsible for the expression of the sialyl-Tn O-glycan in breast cancers, J Biol Chem, 281:3586-94



Bohnenkamp HR, Burchell J, Taylor-Papadimitriou J, Noll T (2005) Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cells, Journal of Immunol Methods, 294(1-2):67-80.


Rughetti A, Pellicciotta I, Biffoni M, Bäckström M, Link T, Noll T, Hansson GC, Clausen H, Burchell JM, Taylor-Papadimitriou J, Nuti M (2005) Recombinant   tumor associated   MUC1  impairs differentiation  and function of Dendritic Cells, Journal of Immunology, 174(12):7764-72    


Markotic A, Culic VC, Kurir TT, Meisen I, Büntemeyer HBoraska V, Zemunik T, Petri N, Mesaric M, Peter-Katalinic J, müthing J (2005), Oxygenation alters ganglioside expression in rat liver following partial hepatectomy, Biochem Biophys Res Commun, 330: 131-141


Schroeder M, Niebruegge S, Werner A, Willbold E, Burg M, Ruediger M, Field LJ, Lehmann J, Zweigerdt R (2005), Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control, Biotechnol Bioeng, 92(7):920-33



Kreikemeyer B., Oehmcke S., Nakata M., Hoffrogge R., Podbielski A. (2004), Streptococcus pyogenes fibronectin-binding protein F2: expression profile, binding characteristics and impact on eukaryotic cell interactions. J. Biol. Chem., 279 (16): 15850-15859


Madi A., Hoffrogge R., Blasko B., Glocker M.O., Fesus L. (2004), Amine donor protein substrates for transglutaminase activity in Caenorhabditis elegans. Biochemical and Biophysical Research Communications 315: 1064-1069


Link T, Backstrom M, Graham R, Essers R, Zörner K, Gätgens J, Burchell J, Taylor-Papadimitriou J, Hansson G, Noll T (2004), Bioprocess development for a recombinant Mucin-1 fusion protein expressed by CHO cells in protein-free medium, J Biotechnol, 110, 51-62     


Bohnenkamp, H; Coleman, J; Burchell, J; Taylor-Papadimitriou, J; Noll, T (2004) Breast carcinoma cell lysate-pulsed dendritic cells cross-prime MUC1 specific cytotoxic T-cells identified by peptide-MHC-class-I tetramers, Cellular Immunology, 231:112 



Hoffrogge R., Mikschofsky H., Piechulla B. (2003), Surface Plasmon Resonance Spectroscopy (SPR) interaction studies of the circadian controlled tomato LHCa4*1 (cab 11) protein with its promoter. Chronobiol. Int. 20 (4): 543-558


Bäckström M, Link T, Olson FJ, Karlsson H, Graham R, Picco G, Burchell J, Taylor-Papadimitriou J, Noll T, Hansson GC (2003) Recombinant MUC1 with breast cancer-like O-glycosylation produced in large amounts in CHO-K1 cells, Biochem J, 376, 677-686


Noll T (2003) Stammzellen – Möglichkeiten ihrer Expansion am Beispiel hämatopoetischer Stammzellen aus Nabelschnurblut, Med Klin, 98, Suppl II: 7-10         


Bohnenkamp H, Noll T (2003) Process Development for standardized generation of mature monocyte-derived dendritic cells suitable for clinical application, Cytotechnology, 42, 121-131        



Noll T, Jelinek N, Schmidt S, Biselli M, Wandrey M (2002): Cultivation of Hematopoietic Stem and Progenitor Cells: Biochemical Engineering Aspects. Advances in Biochemical Engineering and Biotechnology, Vol. 74, 111-128      


Noll T, Eisenkrätzer D, Kiesewetter A, Dinter A, Zeng S, Wandrey C, Biselli M, Berger EG (2002): Improved product formation in high density Chinese hamster ovary cell cultures transfected at confluency. Biotechnol Lett, 24, 861-866           


Bohnenkamp H, Hilbert U, Noll T (2002) Bioprocess Development for the Cultivation of human T-lymphocytes in a clinical scale, Cytotechnology, 38, 135-145  






Wingens M, Gätgens J, Hoffrogge R, Noll T (2008), Proteomic characterization of a glucose-limited CHO perfusion process-analysis of metabolic changes and increase in productivity, Noll (ed.) 'Cells & Culture', Springer, in press


Northoff S, Sandig V, Zietze S, Büntemeyer H, Noll T (2008), Characterization of the novel human AGE1hn cell line for production of recombinant proteins, Noll (ed.) 'Cells & Culture', Springer, in press



Nottorf T, Hoera W, Büntemeyer H, Siwiora-Brenke S, Loa A, Lehmann J (2008), Production of human growth hormone in a mammalian cell high density perfusion process, Smith (ed) ‘Cell Technology for Cell Products’, Springer, Dordrecht, 789-793


Schaper J, Bohnenkamp HR, Noll T (2007), New electrofusion devices for the improved generation of dendritic cell-tumour cell hybrids, Smith (ed) ‘Cell Technology for Cell Products’, Springer, 207-216


Lamlé J, Büntemeyer H, Reinel A, Menne T, van den Bos C, Lehmann J (2005), Propagation of USSC for theraoeutic approaches, Smith (ed) ‘Cell Technology for Cell Products’, Springer, 325-329


Bauwens A, Büntemeyer H, Terstegge S, Nottorf T, Brüstle O, Lehmann J (2005), Bioreactor based production of functional conditioned medium for the propagation of undifferentiated human embryonic stem cells, Smith (ed) ‘Cell Technology for Cell Products’, Springer, 331-334


Jockwer A, Klinger C, Gätgens J, Eisenkrätzer D, Noll T (2007), Towards pCO2-optimized fermentations – reliable sampling, pCO2 control & cellular metabolism, Smith (ed) ‘Cell Technology for Cell Products’, Springer, 509-518


Schomberg M, Hakemeyer C, Buentemeyer H, Stiens L, Lehmann J (2007), Growth promoting effect of a hydrolysate primatone on hybridoma cells (2007), Smith (ed) `Cell Technology for Cell Products´, Springer, 141 - 146


Niebruegge S, Ebelt H, Jungblut M, Baer H, Schroeder M, Zweigerdt R, Braun T, Lehmann J, (2007), `Generation of Cardiomyocytes derived from mouse ESC in a Scale-up System, Smith (ed) `Cell Technology for Cell Products´, Springer, 191 – 195


Nottorf T, Hoera W, Buentemeyer, Siwiora-Brenke S, Loa A, Lehmann J, (2007), Production of human growth hormone in a mammalian cell high density perfusion process, `Cell Technology for Cell Products´, Springer, 789 – 793



Link T, Essers R, Zörner K, de Graaf A, Bäckström M, Hansson G, Noll T (2005) Development of metabolically optimized fermentation process based on glucose-limited CHO perfusion culture, Godia (ed.) ‘Animal Cell Technology meets Genomics’, Kluwer Academic Publishers, Dordrecht, 423-30  


Fischbach, Noll T (2005) Membrane-separated cocultivation of cord blood hematopoietic stem cells with stromal cell lines, Godia (ed.) ‘Animal Cell Technology meets Genomics’, Kluwer Academic Publishers, 269-71


Bohnenkamp HR, Noll T (2005) Process development for standardized generation of monocyte-derived dendritic cells: Applicability in breast cancer immunotherapy, Godia (ed.) ‘Animal Cell Technology meets Genomics’, Kluwer Academic Publishers, 221-27


Schomberg M, Hakemeyer C, Büntemeyer C, Stiens L, Lehmann J (2005), Growth promoting effect of a hydrophilic fraction of the protein hydrophilic fraction of the protein hydrolysate Primatone on hybridoma cells, Smith (ed) ‘Cell Technology for Cell Products’, Springer, Dordrecht, 141-146


Iding K, Buentemeyer H, Lehmann, J (2005), Non-freezing preservation and subsequent recovery of hepatocytes uner pO2 – and pH-controlled conditions for continuous suppy of cells for bioartificial liver support, Gòdia, Fussenegger (eds) `Animal Cell Technology meets Genomics´, Springer, 167 – 170


Schroeder M, Niebruegge S, Werner A, Zweigerdt R, Burg M, Lehmann J, (2005), Optimizing the production of cardiomycytes from mouse embryonic stem cells in a 2L stirred tank reactor,Gòdia, Fussenegger (eds) `Animal Cell Technology meets Genomics´, Springer, 285 – 288